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Introduction: Vati Kalpana (tablet or pill preparations) represents one of the most widely used dosage forms in Ayurveda due to its convenience, stability, and patient acceptability. Despite its long-standing use, issues related to standardization, stability, and quality control remain critical for ensuring therapeutic efficacy and global acceptance. Methods: A systematic review was conducted by consulting Ayurvedic classics (Charaka Samhita, Sushruta Samhita, Sharangadhara Samhita, Bhaishajya Ratnavali) and modern scientific literature from PubMed, Scopus, and Web of Science. Inclusion criteria comprised experimental studies, review articles, and clinical reports addressing Vati preparation, standardization, and stability. Exclusion criteria included non-classical dosage forms or studies without methodological rigor. Results: Classical Vati preparation emphasizes purification of raw materials, proper trituration, and binding agents for stability. Modern pharmaceutical approaches validate these principles with advanced analytical techniques such as HPTLC, HPLC, FTIR, and microbial assays. Studies highlight variability in particle size, moisture content, microbial contamination, and shelf-life as key challenges. Shelf-life of Vati preparations ranges from 1–3 years depending on ingredients, preparation methods, and storage. Emerging evidence suggests that incorporation of modern excipients and packaging techniques (blister packs, desiccants) can significantly enhance stability. Discussion: Integrating classical wisdom with modern pharmaceutical standards can optimize Vati formulations for consistency and safety. Challenges remain in harmonizing Ayurvedic principles with global regulatory requirements. Large-scale stability studies, real-time and accelerated shelf-life assessments, and pharmacokinetic evaluations are needed for wider clinical acceptance. Conclusion: Vati Kalpana exemplifies the adaptability of Ayurveda, but standardization and stability remain central concerns. Bridging classical pharmaceutics with modern quality assurance can enhance global recognition and integration of these formulations into mainstream healthcare.

KEYWORDS: Ayurveda, standardization, stability, tablet, Vati Kalpana