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Introduction: Amritikarana is a distinctive pharmaceutical process in Rasashastra that enhances the safety, stability, and therapeutic efficacy of Bhasmas (incinerated metal/mineral preparations). Derived from the Sanskrit term Amrita (nectar of immortality), Amritikarana symbolizes the transformation of potentially toxic substances into safe, biocompatible medicines. Despite its classical importance, the process has only recently been explored through modern analytical techniques. Methods: A systematic review of Ayurvedic classics (Rasatarangini, Rasa Ratna Samuccaya, Ayurveda Prakasha) was combined with modern scientific literature sourced from PubMed, Scopus, and Web of Science. Search terms included “Amritikarana,” “Rasashastra detoxification,” “Bhasma safety,” and “Ayurveda pharmaceutics.” Inclusion criteria were classical descriptions, pharmaceutical significance, toxicological studies, and modern analytical validations. Results: Classical texts describe Amritikarana as the final step in Bhasma preparation, often involving trituration of the Bhasma with ghee or specific herbal media, followed by controlled heating. This process improves organoleptic properties, reduces residual toxicity, and enhances shelf life. Modern studies confirm that Amritikarana reduces free metal content, introduces organic moieties from the media, and stabilizes the nano- and micro-particles formed during Marana. Analytical tools such as SEM, TEM, XRD, FTIR, and ICP-MS reveal improved particle homogeneity and reduced toxicity. Preclinical evidence supports its role in minimizing adverse effects while maintaining therapeutic efficacy. Discussion: Amritikarana is not merely a ritualistic practice but a scientifically valid pharmaceutical principle ensuring safety and efficacy of herbo-mineral formulations. However, standardization, toxicological profiling, and clinical trials remain insufficient. Conclusion: The principle of Amritikarana exemplifies the scientific foresight of Ayurveda. Integrating its classical wisdom with modern analytical validation is essential to establish globally accepted standards for safe and effective herbo-mineral medicines.

KEYWORDS: Amritikarana, Ayurveda, Bhasma, Rasashastra, Safety