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Introduction: Rasashastra and Bhaishajya Kalpana, the core pharmaceutical branches of Ayurveda, emphasize precise preparation of herbal and herbo-mineral formulations to ensure therapeutic efficacy and safety. In modern times, increasing demand for Ayurvedic medicines has highlighted the importance of Good Manufacturing Practices (GMP) in guaranteeing product quality, safety, and global acceptability. Methods: A structured literature review was conducted across PubMed, Scopus, Web of Science, AYUSH Research Portal, and Google Scholar (2000–2025). Ayurvedic classical texts including Charaka Samhita, Sushruta Samhita, Rasa Ratna Samucchaya, and Ayurveda Sara Sangraha were consulted to trace traditional pharmaceutical quality-control principles. Studies included regulatory guidelines, toxicological assessments, clinical reports, and reviews addressing GMP in Ayurvedic pharmaceutics. Results: Classical texts emphasize raw material authentication, Shodhana (purification), Marana (incineration), proper storage, and ethical dispensing. These align with modern GMP principles such as raw material quality control, process validation, hygiene, record-keeping, and quality assurance. Evidence shows that Ayurvedic medicines manufactured under GMP-certified facilities exhibit improved safety, reduced contamination, and higher therapeutic reliability. Failures in GMP compliance are strongly correlated with instances of heavy metal contamination, adulteration, and loss of credibility in global markets. Discussion: GMP provides a bridge between classical Rasashastra–Bhaishajya Kalpana protocols and modern pharmaceutical requirements. Integration ensures safety, efficacy, and international acceptance. Challenges remain in harmonizing traditional methods with industrial scalability, ensuring trained manpower, and aligning with international regulations. Conclusion: GMP is indispensable for safeguarding the credibility of Ayurveda. Strict adherence ensures consumer safety, scientific validation, and global recognition, making it essential for the future sustainability of Rasashastra and Bhaishajya Kalpana.

KEYWORDS: Ayurveda, Bhaishajya Kalpana, GMP, quality assurance, Rasashastra