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Introduction: Panchavidha Kashaya Kalpana, described in the classical Ayurvedic pharmaceutics, represents five fundamental dosage forms: Swarasa (fresh juice), Kalka (paste), Kwatha (decoction), Hima (cold infusion), and Phanta (hot infusion). These preparations form the foundation of Ayurvedic drug delivery and exhibit diverse pharmacological potentials based on extraction methods, solubility, and bioavailability of phytoconstituents. Despite their central role in traditional practice, modern pharmacological and clinical validations are still emerging. Methods: This review was conducted by systematically searching databases such as PubMed, Scopus, Web of Science, AYUSH Research Portal, and Google Scholar for studies on Panchavidha Kashaya Kalpana. Classical Ayurvedic texts including Charaka Samhita, Sushruta Samhita, and Sharangadhara Samhita were consulted. Inclusion criteria were experimental, pharmacological, and clinical studies that explored preparation methods, phytochemical profiles, and therapeutic applications. Results: Evidence suggests that each formulation possesses unique extraction dynamics: Swarasa provides maximum phytochemical concentration; Kalka enables topical and systemic utility; Kwatha extracts thermostable alkaloids, tannins, and glycosides; Hima retains heat-sensitive compounds; and Phanta facilitates extraction of aromatic principles. Clinical studies reveal their application in fever, digestive disorders, respiratory ailments, wound healing, and inflammatory conditions. Modern studies confirm activities such as antioxidant, antimicrobial, anti-inflammatory, immunomodulatory, and adaptogenic effects. Discussion: Bridging classical insights with modern pharmacology reveals significant potential for developing standardized formulations, optimized extraction techniques, and novel dosage forms. However, challenges remain in stability studies, pharmacokinetic profiling, and randomized clinical trials. Conclusion: Panchavidha Kashaya Kalpana, when validated through contemporary research, offers promising opportunities for evidence-based integration of Ayurvedic pharmaceutics into modern clinical practice.

KEYWORDS: Ayurveda, Clinical applications, Panchavidha Kashaya Kalpana, Pharmacology, Therapeutics