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The field of study known as Bhaishajya Kalpana studies the transformation of basic materials into forms that are suited for therapeutic use. Before modern times, doctors would make their own medications to give to their patients. Dhanvantari sampradaya, which focuses mostly on shalya and shalakya tantra, is home to Sushrutha samhitha. Despite being a Shalya Pradhana work, there are scattered details about pharmaceutics in each part. Here, an attempt has been made to gather the key ideas of Bhaishajya Kalpana as they are presented in the Sushrutha Samhitha.Sushrutha Samhitha was searched literary and themes related to it were searched in peer-reviewed publications.The various notions that were discovered include adharabhutha siddhanta, dravya Sangrahana and samrakshana, details of kshara and sneha kalpana, as well as additional kalpana such as lavana, ayaskruthi, pathya kalpana, and masi kalpana.
In conclusion, the Sushrutha Samhitha originated in antiquity. Information pertaining to Aushadha Nirmana is dispersed throughout all divisions. Information is provided about drug collection, dose forms, and preparation techniques. There was no distinct branch during the Samhitha period for the manufacture of medicines. This suggests that every vaidya had to be aware of bhaishajya kalpana, and that knowledge of it was inescapable.

KEYWORDS: Aushadha Nirmana, Bhaishajya Kalpana, Pharmaceutics and Sushrutha Samhitha